Molecular diagnosis angioimmunoblastic T-cell lymphoma
نویسندگان
چکیده
منابع مشابه
Angioimmunoblastic T-cell lymphoma
The lymphoma cell is a peripheral T lymphocyte in various stages of differentiation. The neoplastic clone expresses T-cell antigens and is usually CD4+. The malignant T-cells are believed to secrete cytokines responsible for the polyclonal B-cell hyperplasia observed in involved nodes. Clonality studies demonstrated a monoclonal rearrangement of the bchain of the T-cell receptor (TCR) in the ma...
متن کاملAngioimmunoblastic T-cell lymphoma management.
Angioimmunoblastic T-cell lymphoma (AITL) is a frequent subtype of peripheral T-cell lymphoma (PTCL) that is clinically characterized by generalized lymphadenopathy, extranodal involvement, advanced stage at presentation, hypergammaglobulinemia, and significant immune dysregulation resulting in infections as the most common cause of death. Recent advances in pathobiology of AITL have improved o...
متن کاملConjunctival Angioimmunoblastic T-Cell Lymphoma.
Angioimmunoblastic T-cell lymphoma (AITL) represents an uncommon variant of T-cell lymphomas and most often presents insidiously with systemic symptoms. This report constitutes the first documented case of conjunctival AITL, masquerading as nodular episcleritis, and describes both the clinical and pathological findings. Furthermore, conjunctival T-cell lymphoma in general remains a rare occurre...
متن کاملMolecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma.
Peripheral T-cell lymphoma (PTCL) is often challenging to diagnose and classify. Gene expression profiling was performed on 144 cases of PTCL and natural killer cell lymphoma and robust molecular classifiers were constructed for angioimmunoblastic T-cell lymphoma (AITL), anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large-cell lymphoma (ALCL), and adult T-cell leukemia/lymphoma. PTCL-...
متن کاملLYMPHOID NEOPLASIA Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma
Departments of 1Pathology and Microbiology, 2Hematology/Oncology, and 3Preventive Medicine, University of Nebraska Medical Center, Omaha; 4Department of Hematology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark; 5Aichi Cancer Center, Nagoya, Japan; 6Norwegian Radium Hospital, Oslo; Norway; 7Centre Hospitalier Lyon-Sud, Lyon, France; 8Queen Mary Hospital, Hong Kong, China; 9Sams...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Terapevticheskii arkhiv
سال: 2019
ISSN: 2309-5342,0040-3660
DOI: 10.26442/00403660.2019.07.000330